Tabriz University of Medical Sciences Depiction of Health 2008-9058 13 1 2022 03 21 Zoning and Identification of Factors Affecting Premature Death Registration 70 82 10.34172/doh.2022.06 EN Ehsan Iravani https://orcid.org/0000-0001-5862-8544 Majid Mirmohamadkhani https://orcid.org/0000-0001-6251-7484 Elham Gholami https://orcid.org/0000-0002-0511-2402 Mojtaba Soltani-Kermanshahi https://orcid.org/0000-0002-6607-6249 Journal Article 10.34172/doh.2022.06 2021 08 12 2021 10 12 Background. Different types of deaths among people indicate the quality of healthcare and the growth and development of a society. Premature mortality imposes a heavy burden on society in terms of health, economy, and mental issues. Given the preventability of these deaths, health officials anticipate to reduce premature mortality by 25 percent by 2025. Methods. This descriptive-analytical study aimed to perform zoning of premature deaths in the cities supervised by Semnan University of Medical Sciences, and investigate the factors affecting the premature deaths to reduce premature mortality, especially among individuals aged 30 to 69. We studied 3,619 death records extracted from Death Registration System’s database from 2013 to 2018 and analyzed the data using Statistical Package for the Social Sciences (SPSS) software v.18, descriptive statistics (relative frequency, mean, and standard deviation), and inferential tests (chi-square and independent t-test). The level of significance was considered as 0.05. Results. The mean and standard deviation of premature mortality was 55.7 ± 10.6 and most of the deaths occurred in the seventh decade of life. Premature mortality was more common among males, employed individuals, and urban residents. Cardiovascular diseases, cancer, and accidents are the leading causes of premature mortality. Conclusion. The results showed that accidents are the major cause of premature mortality among the young, while chronic and non-communicable diseases cause most death among middle-aged individuals. Therefore, in order to reduce the risk factors regarding premature mortality, collaboration of the related organizations is essential.