Abstract
Background. Wilms tumor (nephroblastoma) is one of the most common malignantkidney cancers in childhood, accounting for approximately 6% of all pediatric cancers.Given the increasing volume of research in this field, a scientometric analysis has becomeessential to evaluate the scientific structure, research trends, and identify existing gaps inthe literature.
Methods. This study employs a descriptive-analytical approach with a scientometricmethodology. Data were extracted from the Scopus database using keywords related toWilms tumor up to November 2024. Analytical tools included Bibliometrix software (Rpackage) and VOSviewer. Key metrics examined were annual publication trends,authorship and country collaboration networks, citation metrics, top journals andinstitutions, and keyword co-occurrence analysis.
Results. A total of 14,049 scientific documents were identified from 1934 to 2025. TheUnited States, China, and Japan contributed the highest scientific output. Pediatric Bloodand Cancer and Journal of Pediatric Surgery were among the most cited journals in thisfield. Frequent keyword analysis revealed increasing trends in topics related to WT1 gene,biomarkers, targeted therapies, and genetic syndromes (e.g., Denys-Drash). Collaborationnetworks highlighted the central role of developed countries in knowledge production.
Conclusion. This study confirms the growing research interest in Wilms tumor. However,an uneven geographical distribution of scientific output and research gaps in patientspecific genetics, novel therapies, and multi-omics studies remain evident. These findingscan assist health policymakers, research institutions, and researchers in planning futurestudies in pediatric cancers, particularly Wilms tumor.